![]() ![]() Published by Cambridge University Press, 2020. This work was supported by grants from the National Institute on Aging/National Institutes of Health (P30 AG013854, R01 NS075075, R01 AG056258), the National Institute on Deafness and Other Communication Disorders/National Institutes of Health (R01 DC008552), a National Alzheimer’s Coordinating Center New Investigator Award (U01 AG016976), and the Florane and Jerome Rosenstone Fellowship.Ĭopyright © INS. T1 - Montreal Cognitive Assessment (MoCA) Performance and Domain-Specific Index Scores in Amnestic Versus Aphasic Dementia Multivariate logistic regression analysis showed that the individual effects of Memory (p =.001), Language (p =.002), and Orientation (p =.025) Indices were significant.Conclusions: MoCA Index scores can help differentiate among distinct cognitive syndromes, suggesting it may be a useful brief screening tool to detect domain-specific cognitive impairment.", However, in accordance with salient clinical features commonly observed in DAT versus PPA, Memory and Orientation Index scores were lowest in the DAT group (p <.001), whereas Language and Attention Index scores were lowest in the PPA group (p <.001). ![]() A logistic regression model was implemented to observe individual likelihood of group affiliation based on MoCA Index scores.Results: The mean MoCA total score was significantly higher in controls compared to both patient groups (p <.001) but did not differ between DAT and PPA groups. A one-way analysis of covariance adjusted for age was used to compare MoCA scores among groups. This study compared MoCA Index scores between amnestic dementia of the Alzheimer's type (DAT) and primary progressive aphasia (PPA), a language-based dementia.Method: Baseline MoCA data were analyzed from 33 DAT, 37 PPA, and 83 cognitively normal individuals enrolled in the Clinical Core of the Northwestern Alzheimer's Disease Center. It is unclear whether these MoCA scores can differentiate between distinct clinical dementia syndromes. The MoCA generates a total score and six domain-specific index scores: (1) Memory, (2) Executive Functioning, (3) Attention, (4) Language, (5) Visuospatial, and (6) Orientation. Multivariate logistic regression analysis showed that the individual effects of Memory (p =.001), Language (p =.002), and Orientation (p =.025) Indices were significant.Conclusions: MoCA Index scores can help differentiate among distinct cognitive syndromes, suggesting it may be a useful brief screening tool to detect domain-specific cognitive impairment.Ībstract = "The Montreal Cognitive Assessment (MoCA) is a popular and simple-to-administer screening instrument to detect cognitive impairment. ![]() ![]() The Montreal Cognitive Assessment (MoCA) is a popular and simple-to-administer screening instrument to detect cognitive impairment. ![]()
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